Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects

Fathoni, M. Ivan Ariful and Adi-Kusumo, Fajar and Gunardi, Gunardi and Hutajulu, Susanna Hilda (2021) Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects. Hindawi International Journal of Differential Equations.

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Abstract

Breast cancer is a type of carcinoma with a high prevalence. .e treatment of breast cancer through chemotherapy can cause a risk to healthy cells throughout the body. .e neutrophil is one of the cells that is influenced by chemotherapy drugs. Chemotherapyinduced neutropenia is one of the most common toxic effects experienced by patients and often threatens chemotherapy to use efficiency. In this paper, we introduce an interaction model between blood components, i.e., neutrophil, lymphocytes, and albumin, with chemotherapy drugs. .e model is important to understand the neutropenia effect due to chemotherapy in mathematical perspective and to calculate breast cancer patients’ survival level. Our model is a four-dimensional system of the first-order ODE with 13-dimensional parameter space. We focus our study for understanding the steady-state conditions and the bifurcations when the parameter values are varied. Here, we also study the role of albumin for reducing the neutropenia effects for breast cancer patients mathematically, where the results can be used as an alternative solution for treating neutropenia in a breast cancer case.

Item Type: Article
Subjects: 600 – Teknologi (Ilmu Terapan) > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan
600 – Teknologi (Ilmu Terapan) > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan > 615 Farmakologi dan terapi farmakologi
Divisions: Fakultas Keguruan dan Ilmu Pendidikan > Pendidikan Matematika
Depositing User: Perpustakaan Pusat Admin
Date Deposited: 11 Apr 2023 03:04
Last Modified: 11 Apr 2023 03:04
Contributors (Pembimbing / Pengarah):
Contribution
Name
NIDN
Author
Fathoni, M. Ivan Ariful
NIDN0705019103
Author
Adi-Kusumo, Fajar
NIDN0000000000
Author
Gunardi, Gunardi
NIDN0000000000
Author
Hutajulu, Susanna Hilda
NIDN0000000000
URI: https://repository.unugiri.ac.id/id/eprint/2435

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