Fathoni, M. Ivan Ariful and Adi-Kusumo, Fajar and Gunardi, Gunardi and Hutajulu, Susanna Hilda (2021) Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects. Hindawi International Journal of Differential Equations.
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Abstract
Breast cancer is a type of carcinoma with a high prevalence. .e treatment of breast cancer through chemotherapy can cause a risk to healthy cells throughout the body. .e neutrophil is one of the cells that is influenced by chemotherapy drugs. Chemotherapyinduced neutropenia is one of the most common toxic effects experienced by patients and often threatens chemotherapy to use efficiency. In this paper, we introduce an interaction model between blood components, i.e., neutrophil, lymphocytes, and albumin, with chemotherapy drugs. .e model is important to understand the neutropenia effect due to chemotherapy in mathematical perspective and to calculate breast cancer patients’ survival level. Our model is a four-dimensional system of the first-order ODE with 13-dimensional parameter space. We focus our study for understanding the steady-state conditions and the bifurcations when the parameter values are varied. Here, we also study the role of albumin for reducing the neutropenia effects for breast cancer patients mathematically, where the results can be used as an alternative solution for treating neutropenia in a breast cancer case.
Item Type: | Article |
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Subjects: | 600 – Teknologi (Ilmu Terapan) > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan 600 – Teknologi (Ilmu Terapan) > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan > 615 Farmakologi dan terapi farmakologi |
Divisions: | Fakultas Keguruan dan Ilmu Pendidikan > Pendidikan Matematika |
Depositing User: | Perpustakaan Pusat Admin |
Date Deposited: | 11 Apr 2023 03:04 |
Last Modified: | 11 Apr 2023 03:04 |
Contributors (Pembimbing / Pengarah): | Contribution Name NIDN Author Fathoni, M. Ivan Ariful NIDN0705019103 Author Adi-Kusumo, Fajar NIDN0000000000 Author Gunardi, Gunardi NIDN0000000000 Author Hutajulu, Susanna Hilda NIDN0000000000 |
URI: | https://repository.unugiri.ac.id/id/eprint/2435 |